Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetonitrile → Ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| 반응물 | 2-Chloro-6-methoxyquinoline | HCID 83647 | — |
| 생성물 | Ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate | HCID 66980031 | — |
반응 단계
Ethyl piperidine-4-carboxylate (100 mg) was treated with 2-chloro-6-methoxyquinoline (Intermediate 1) (90 mg) in MeCN (0.8 mL) and TEA (100 mg) in a sealed tube at 180° C. for 6 h in a microwave reactor. After aqueous work-up with EtOAc and column purification, eluting with EtOAc/hexane, ethyl 4-(6-methoxyquinolin-2-yl)cyclohexanecarboxylate (90 mg) was afforded as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09433618B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-550c1e91025842e7bcb55db1293d04a9 |
| 출처 메모 | uspto-grants-2016_09 |