Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 559585생성일: 2026년 10월 24일
8-Hydroxyquinoline → 5-chloro-N-((1-(4-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide
https://huagongshe.com/ko/reaction/559585
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 8-Hydroxyquinoline | HCID 1923 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Methyluracil | HCID 79066 | — |
| 반응물 | 5-Chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide | HCID 24986897 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 5-chloro-N-((1-(4-(3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide | HCID 24760161 | 22.6% |
반응 단계
A mixture of 5-chloro-N-((1-(4-iodophenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide 1-6 (66 mg, 0.15 mmol), 3-methyluracil (60 mg, 0.48 mmol), 8-hydroxyquinoline (10 mg, 0.069 mmol) and K2CO3 (60 mg, 0.43 mmol) in DMSO (1 mL) was degassed with Ar before being charged with CuI (15 mg, 0.079 mmol). The mixture in a sealed tube was heated at 130° C. overnight. The mixture was then purified by HPLC to give the titled compound (15 mg). MS 442.2 and 444.2 (M+H, Cl pattern).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08063077B2 |
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| 출처 데이터셋 | uspto-grants-2011_11 |
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| ORD ID | ord-f6632a6f1a684812871b6bebd0e33e71 |
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| 출처 메모 | uspto-grants-2011_11 |
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