Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 4-(2-Methylpropoxy)-3-nitrobenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | Isobutanol | HCID 6560 | — |
| 반응물 | 4-Fluoro-3-nitrobenzaldehyde | HCID 598129 | — |
| 반응물 | 5-Formyl-2-(2-methylpropoxy)aniline | HCID 82057088 | — |
| 생성물 | 4-(2-Methylpropoxy)-3-nitrobenzaldehyde | HCID 28829481 | 75% |
| 생성물 | 1-(5-Formyl-2-isobutoxy-phenyl)-3-thiazol-2-yl-urea | HCID 59732785 | 65% |
반응 단계
4-(2-Methylpropoxy)-3-nitrobenzaldehyde (0.83 g, 75%) was prepared from 2-methyl-propanol (0.46 ml, 5.0 mmol) and 4-fluoro-3-nitrobenzaldehyde (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 5-formyl-2-(2-methylpropoxy)-aniline (0.49 g, 68%) following general procedure B. 1-(5-Formyl-2-isobutoxy-phenyl)-3-thiazol-2-yl-urea (208 mg, 65%) was prepared from 5-formyl-2-(2-methylpropoxy)aniline (193 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08063081B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-6cefdb189f764a7e8401656c012f3ab0 |
| 출처 메모 | uspto-grants-2011_11 |