Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(2-Fluoro-4-nitrophenyl)morpholine → 3-Fluoro-4-morpholinoaniline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(2-Fluoro-4-nitrophenyl)morpholine | HCID 2905489 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3-Fluoro-4-morpholinoaniline | HCID 1485330 | 89.2% |
반응 단계
To a solution of 4-(2-fluoro-4-nitrophenyl)morpholine (15.0 g, 66 mmol) in THF (100 mL) was added Pd/C (3.0 g). The reaction mixture was stirred at rt under H2 for 12 h. The mixture was filtered through a celite pad, and the filtrate was concentrated in vacuo to give the title compound as a white solid (11.55 g, 89%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434695B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-51ae4d6c3bc14006be06859f8f9f4628 |
| 출처 메모 | uspto-grants-2016_09 |