참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Lawesson's reagent | HCID 87949 | — |
| 반응물 | 4-(Morpholin-4-yl)benzamide | HCID 22142242 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Morpholinobenzenecarbothioamide | HCID 2795360 | 83.4% |
반응 단계
To a solution of 4-morpholinobenzamide (4.91 g, 23.80 mmol) in THF (70 mL) was added Lawesson's Reagent (10.60 g, 26.20 mmol) with stirring. The mixture was heated at 70° C. for 4 h, then cooled to rt and concentrated in vacuo. CH2Cl2 (30 mL) and water (100 mL) was added to the residue. The mixture was then filtered and the filter cake was washed with water and dried to give the title compound as a yellow solid (4.41 g, 83.3%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09434695B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-b3263675a8b3462c97d4844f0524773b |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
