Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 1-(2-Fluoro-4-nitrophenyl)piperidin-4-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Piperidin-4-ol | HCID 79341 | — |
| 반응물 | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(2-Fluoro-4-nitrophenyl)piperidin-4-ol | HCID 26598221 | 80.5% |
반응 단계
To a solution of piperidin-4-ol (11.11 g, 0.11 mol) and Et3N (12.14 g, 0.12 mol) in EtOAc (500 mL) was added 1,2-difluoro-4-nitrobenzene (15.91 g, 0.10 mol). The mixture was stirred at rt for 24 h, and washed with water (200 mL×4). The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as orange oil (19.35 g, 80%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434695B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-a558440d17004c44b2cb7ddab9285113 |
| 출처 메모 | uspto-grants-2016_09 |