1-(2-Fluoro-4-nitrophenyl)piperidin-4-ol → 1-(4-Amino-2-fluorophenyl)piperidin-4-ol

HRID 56153

반응식

HRID 56153 반응식
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[N:11]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]1>CO.[Pd]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([N:11]2[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]2)=[C:2]([F:1])[CH:7]=1

참가 물질

4

반응물 1

HCID 265982211-(2-Fluoro-4-nitrophenyl)piperidin-4-ol

생성물 1

HCID 289725861-(4-Amino-2-fluorophenyl)piperidin-4-ol수율 108.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 1-(2-fluoro-4-nitrophenyl)piperidin-4-ol (2.67 g, 11 mmol) in MeOH (100 mL) was added catalyst Pd/C (1.00 g). The reaction mixture was stirred at rt under H2 for 6 h, then filtered. The filtrate was concentrated in vacuo to give the crude product (2.50 g) for the next step without further purification.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-144c800e0cda4e159c90c2438879491e
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09434695B2

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