참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | 1-(3,4-Dichlorophenyl)-2-hydroxyethan-1-one | HCID 7062193 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 4-(3,4-Dichlorophenyl)-2-oxazolone | HCID 12992960 | 52% |
반응 단계
A mixture of 2-hydroxy-3′,4′-dichloroacetophenone (10.3 g), potassium cyanide (8.1 g) and 2-propanol (100 ml) was heated to 50° C., to which was added dropwise acetic acid (6.0 g) gradually and stirred at 50° C. for 2 hours. The reaction mixture was concentrated and poured into ice water (200 ml). The solid precipitates were filtered, washed with water, and air-dried to give crystals of 4-(3′,4′-dichlorophenyl)-2-oxazolone (6.0 g, 52%). Recrystallization from tetrahydrofuran-hexane gave pale yellow prisms. Melting point 262-263° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08067453B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-754d94d888d74b9aa62a12e15ec36b6b |
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| 출처 메모 | uspto-grants-2011_11 |
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