Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Methoxycinnamic Acid → N-[(S)-1-benzyl-2-(4-benzyl-piperazin-1-yl)-2-oxo-ethyl]-3-(3-methoxy-phenyl)-N-(4-pentyl-benzyl)-acrylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Methoxycinnamic Acid | HCID 637668 | — |
| 반응물 | 1-(4-benzyl-piperazin-1-yl)-(S)-2-(4-pentyl-benzylamino)-3-phenyl-propan-1-one | HCID 59808255 | — |
| 생성물 | N-[(S)-1-benzyl-2-(4-benzyl-piperazin-1-yl)-2-oxo-ethyl]-3-(3-methoxy-phenyl)-N-(4-pentyl-benzyl)-acrylamide | HCID 67005387 | 54% |
반응 단계
Acylation of 1-(4-benzyl-piperazin-1-yl)-(S)-2-(4-pentyl-benzylamino)-3-phenyl-propan-1-one (43.5 mg, 0.09 mmol) according to the procedure described for the preparation of Example 1 with trans-3-methoxy-cinnamic acid (17.6 mg, 0.099 mmol) gave 31.3 mg (54%) of N—[(S)-1-benzyl-2-(4-benzyl-piperazin-1-yl)-2-oxo-ethyl]-3-(3-methoxy-phenyl)-N-(4-pentyl-benzyl)-acrylamide. LC-MS: tR=1.01 min; [M+H]+=644.50.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08067419B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-102c1496f6194c99b080b41b7a47b549 |
| 출처 메모 | uspto-grants-2011_11 |