Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 56374생성일: 2026년 10월 23일
1,8-Diazabicyclo(5.4.0)undec-7-ene → tert-butyl ((1S,2R)-2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)cyclohexyl)carbamate
https://huagongshe.com/ko/reaction/56374
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | (1S,2R)-Cyclohexane-1,2-diamine, N1-BOC protected | HCID 1514389 | — |
| 반응물 | 2-Chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline | HCID 89921772 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | tert-butyl ((1S,2R)-2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)cyclohexyl)carbamate | HCID 118043439 | 81% |
반응 단계
A mixture of 2-chloro-6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazoline (0.95 g, 2.6 mmol), tert-butyl ((1S,2R)-2-aminocyclohexyl)carbamate (1.1 g, 5.14 mmol), and DBU (0.77 mL, 5.14 mmol) in acetonitrile (9 mL) was degassed with N2 for 5 mins and heated at 70° C. for 16 h. The mixture was cooled to room temperature, concentrated and the residue was purified by silica gel column chromatography to afford tert-butyl ((1S,2R)-2-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)cyclohexyl)carbamate (1.1 g, 81%). MS (ES+) C27H32Cl2N4O4 requires: 546, found: 547 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09434700B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-69a23d5d36bf4cc69ee11cb718be1394 |
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| 출처 메모 | uspto-grants-2016_09 |
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