Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus tribromide → 4-Bromo-2-(bromomethyl)-1-fluorobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus tribromide | HCID 24614 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | (5-Bromo-2-fluorophenyl)methanol | HCID 2773352 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 4-Bromo-2-(bromomethyl)-1-fluorobenzene | HCID 13553295 | — |
반응 단계
To (5-bromo-2-fluoro-phenyl)-methanol (1.2 g, 5.9 mmol) in DME (20 mL) was added phosphorus tribromide (0.83 mL, 8.8 mmol), and the reaction was stirred at room temperature for 6 hours. The mixture was cooled to 0° C. and adjusted to pH 6 with saturated aqueous NaHCO3. The solution was extracted with EtOAc, and the combined organic layers were dried, concentrated, and purified by silica gel chromatography to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08067445B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-81d61cfb8f294986860eb236a730ea7e |
| 출처 메모 | uspto-grants-2011_11 |