Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → HCID 19831143, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Fumaric Acid | HCID 444972 | — |
| 반응물 | 2-Bromoethylamine hydrobromide | HCID 2774217 | — |
| 반응물 | (-)-2-[(1,4,5,6-Tetrahydropyrimidin-2-yl)thio]methyl-3-carboethoxy-5-carbomethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine | HCID 19796531 | — |
| 촉매 | Hexadecyltributylphosphonium bromide | HCID 84716 | — |
| 용매 | Benzene | HCID 241 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | HCID 19831143 | HCID 19831143 | — |
반응 단계
A mixture of (-)-2-[(1,4,5,6-tetrahydropyrimidin-2-yl)thio]methyl-3-carboethoxy-5-carbomethoxy-4-(m-nitrophenyl)-6-methyl-1,4-dihydropyridine (g 2), hexadecyltributyl phosphonium bromide (mg 180), 2-bromoethylaminehydrobromide (mg 900), NaOH (35%, ml 8) and benzene is stirred for 40 minutes at room temperature. After the usual work-up, an oily residue is obtained that is dissolved in ethyl acetate and treated with fumaric acid to give 1.9 g of (-)-2-(aminoethylthio)methyl-3-carboethoxy-5-carbomethoxy-4-(3-nitrophenyl)-6-methyl-1,4-dihydropyridine fumarate, m.p. 104°-110° C. [α]D =-11 (C=4 in MeOH).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05245039 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-7e2beb4a11a24e89994da680a2a56493 |
| 출처 메모 | uspto-grants-1993_09 |