Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Citric Acid → Veratraldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Citric Acid | HCID 311 | — |
| 반응물 | Veratryl alcohol | HCID 7118 | — |
| 반응물 | Monobasic potassium phosphate | HCID 516951 | — |
| 반응물 | 6-benzothiazolesulfonic acid, 2,2'-azinobis(3-ethyl-2,3-dihydro-, diammonium salt | HCID 9570474 | — |
| 반응물 | 3-amino-N-hydroxyphthalimide | HCID 10888472 | — |
| 반응물 | Dipotassium hydrogen phosphate citric acid | HCID 21698641 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Veratraldehyde | HCID 8419 | 92% |
반응 단계
22 ml of a dipotassium hydrogen phosphate/citric acid buffer solution of pH 4.5 (prepared by titrating a 0.2 M potassium dihydrogen phosphate solution with a 0.1 M citric acid solution and diluting to 1/4) were treated at 45° C. with 269 mg (1.60 mmol) of 3,4-dimethoxybenzyl alcohol in 1 ml of ethanol. 32.1 mg (0.180 mmol) of 3-amino-N-hydroxyphthalimide were added with stirring. After approx. 10 minutes, the mixture was treated with 5 ml of an aqueous solution of 2 mg/ml laccase from Trametes versicolor (specific activity approx. 18 IU/mg, defined with ABTS as substrate). After a reaction time of 22 hours, the reaction solution was extracted with chloroform and examined by NMR spectroscopy. Yield 92% of 3,4-dimethoxybenzaldehyde.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06169213A |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-8e2dfa86321448ad8fab97d35d078bfb |
| 출처 메모 | uspto-grants-2001_01 |