Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Ethyl 4-formylcyclohexane-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethyl cyclohexanoate | HCID 18686 | — |
| 반응물 | Methoxymethyl-triphenylphosphonium chloride | HCID 2723798 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | tert-Butyl methyl ether | HCID 15413 | — |
| 생성물 | Ethyl 4-formylcyclohexane-1-carboxylate | HCID 13548164 | — |
반응 단계
Under a nitrogen atmosphere, 425.5 g of ethyl 4-cyclohexanecarboxylate and 856.7 g of methoxymethyltriphenylphosphonium chloride were suspended in 2.2 l of methyl tert-butyl ether. A solution of 280.4 g of potassium tert-butoxide in 400 ml of tetrahydrofuran was then added dropwise to the stirred suspension. The suspension was then stirred overnight at RT, and the next day 430 ml of 10% hydrochloric acid were added and the mixture was warmed at 55° C. for 1 hour. 50 ml of water were then added to the suspension. Conventional work-up gave ethyl 4-formylcyclohexanecarboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06171664B2 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-2fbd981f82d742268fc37b159a31a054 |
| 출처 메모 | uspto-grants-2001_01 |