참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Indole | HCID 798 | — |
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | Quinoline 1-oxide | HCID 15366 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-(1H-Indol-3-yl)quinoline | HCID 12406622 | 6% |
반응 단계
To a solution of quinoline-N-oxide (0.5 mmol) in 2 mL DCM at 0° C. in a 3 mL plastic tube fitted with a frit was added 58 uL of benzoyl chloride (0.5 mmol). The reaction mixture was stirred for 15 min at 0° C. and then indole (0.5 mmol) was added. The reaction was warmed to 20 ° C. and stirred for 4 h. The solid precipitate was filtered and washed with DCM (3×2 mL) to give solid 2-(3-indolyl)quinoline (6-100% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06172084B2 |
|---|
| 출처 데이터셋 | uspto-grants-2001_01 |
|---|
| ORD ID | ord-f1edd849e7ba4f11bb333748e3a1c4e2 |
|---|
| 출처 메모 | uspto-grants-2001_01 |
|---|
