Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 4-Amino-2-chlorobenzoate → Methyl 2-chloro-4-({2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 4-Amino-2-chlorobenzoate | HCID 11839197 | — |
| 반응물 | 2-[4-(5-Chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid | HCID 117622850 | — |
| 생성물 | Methyl 2-chloro-4-({2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoyl}amino)benzoate | HCID 117622740 | — |
반응 단계
120 mg (0.39 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid (racemate) and 1.1 eq. of methyl 4-amino-2-chlorobenzoate were reacted according to General Method 5A. Following aqueous work-up, the desired product was precipitated using a mixture of a little water, acetonitrile and DMF. Yield: 69 mg (38% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434690B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-cca1fedefeab430780034ca6c75fa814 |
| 출처 메모 | uspto-grants-2016_09 |