Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dichlorobenzeneboronic acid → Tert-butyl 2-(4-(2,5-dichlorophenyl)-2-oxopyridin-1(2h)-yl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dichlorobenzeneboronic acid | HCID 2773371 | — |
| 반응물 | tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate | HCID 117622807 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 생성물 | Tert-butyl 2-(4-(2,5-dichlorophenyl)-2-oxopyridin-1(2h)-yl)propanoate | HCID 117622663 | — |
반응 단계
2.5 g (8.0 mmol) of tert-butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate (racemate) and 1.76 g (9.2 mmol) of 2,5-dichlorophenylboronic acid in the presence of tetrakis(triphenylphosphine)palladium(0) were reacted according to General Method 2A. Yield: 2.3 g (77% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434690B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-6ec48d2ebcd54656ae66b98aa0225caf |
| 출처 메모 | uspto-grants-2016_09 |