Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzocaine → HCID 117622946, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzocaine | HCID 2337 | — |
| 반응물 | Diisopropylcarbodiimide | HCID 12734 | — |
| 반응물 | 2-[4-(5-Chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoic acid | HCID 117622944 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 117622946 | HCID 117622946 | — |
반응 단계
1.50 g (3.98 mmol) of 2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoic acid (racemate), 658 mg (3.98 mmol) of ethyl 4-aminobenzoate, 566 mg (3.98 mmol) of Oxima and 620 μl (3.98 mmol) of DIC in 39 ml of dimethylformamide were reacted according to General Method 5B. Filtration gave the title compound. Yield: 1.87 g (85% of theory)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434690B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-cb217f33cc6a47fd95ab39364bf92558 |
| 출처 메모 | uspto-grants-2016_09 |