Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-[N-(4-Chloro-benzyl)-amino]-cyclohexanone | HCID 13670664 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-[N-(4-Chloro-benzyl)-methylamino]-cyclohexanone | HCID 13670665 | — |
반응 단계
8.4 g (35 mMol) of 4-[N-(4-chloro-benzyl)-amino]-cyclohexanone are dissolved in 50 ml of absolute dimethylformamide and, after the addition of 2.6 g (18.7 mMol) of potassium carbonate, 5.0 g (35 mMol) of methyliodide are added dropwise at 25°-30° C. After standing overnight the mixture is concentrated, mixed with water and extracted with chloroform. The extracts are dried and concentrated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04731374 |
| 출처 데이터셋 | uspto-grants-1988_03 |
| ORD ID | ord-76e9f12e78724b76924af38a90030d39 |
| 출처 메모 | uspto-grants-1988_03 |