참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Chlorobenzimidazole | HCID 78572 | — |
| 반응물 | 5-Bromoindoline | HCID 3411566 | — |
| 용매 | N,N-dimethylformamide N,N-dimethylacetamide | HCID 22628260 | — |
| 생성물 | 2-(5-Bromo-2,3-dihydro-1H-indol-1-yl)-1H-benzimidazole | HCID 66727872 | 69.4% |
반응 단계
A mixture of 5-bromoindoline (1 g) and 2-chloro-1H-benzo[d]imidazole (0.770 g) in DMA/DMF (5 mL, 3/2) was stirred at 150° C. for 12 h, treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (1.1 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09029536B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_05 |
|---|
| ORD ID | ord-382a041251144bd1a58a76f565fcab9f |
|---|
| 출처 메모 | uspto-grants-2015_05 |
|---|
