Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3,3'-Benzene-1,4-diylbis(1-ethyl-1H-pyrazolo[4,3-b]pyridine)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 1,4-Benzenediboronic acid | HCID 230478 | — |
| 반응물 | 3-bromo-1-ethyl-1H-pyrazolo[4,3-b]pyridine | HCID 66727882 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Water 1,2-dimethoxyethane | HCID 18180031 | — |
| 생성물 | 3,3'-Benzene-1,4-diylbis(1-ethyl-1H-pyrazolo[4,3-b]pyridine) | HCID 66728061 | 7.3% |
반응 단계
A mixture of 1,4-phenylenediboronic acid (37.0 mg), 3-bromo-1-ethyl-1H-pyrazolo[4,3-b]pyridine (101 mg), Pd(PPh3)4 (25.8 mg) and Cs2CO3 (0.280 g) in DME/water (3/1, 4 mL) was exposed to microwave irradiation (120° C., 40 min), treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane). Crystallization from AcOEt/hexane gave the title compound (6.00 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09029536B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-860466cb5efe4e0b9b2a630d8f4ba9f7 |
| 출처 메모 | uspto-grants-2015_05 |