Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pramipexole → (-)-N6-(2-(4-(8-((4-Methoxybenzyl)oxy)quinoline-4-yl)piperazine-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pramipexole | HCID 119570 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 2-(4-(8-((4-Methoxybenzyl)oxy)quinoline-4yl)piperazine-1yl)acetaldehyde | HCID 86664666 | — |
| 생성물 | (-)-N6-(2-(4-(8-((4-Methoxybenzyl)oxy)quinoline-4-yl)piperazine-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine | HCID 87424865 | 75% |
반응 단계
Compound 27 (1.0 g, 2.55 mmol) was treated with (−)-pramipexole (599 mg, 2.81 mmol) and NaBH(OAc)3 (973 mg, 4.59 mmol) by following procedure A. The reaction mixture was purified by silica gel column chromatography (EtOAc/MeOH, 9:1) to yield 1.12 g (75%) of compound (−)-28 as yellow solid. The 1H NMR of (−)-28 is similar to compound (±)-28.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09034877B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-ba998cb8b228427cb0ea7cd2157fac5d |
| 출처 메모 | uspto-grants-2015_05 |