Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylamine → N,N-dimethyl-1-(4-nitrophenyl)piperidine-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1-(4-Nitrophenyl)piperidine-4-carboxylic acid | HCID 2767265 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N,N-dimethyl-1-(4-nitrophenyl)piperidine-4-carboxamide | HCID 16370119 | — |
반응 단계
A solution of 1-(4-nitrophenyl)piperidine-4-carboxylic acid, (CH3)2NH (2.37 g, 29.06 mmol), HATU (11.05 g, 29.06 mmol) and DIPEA (7.51 g, 58.12 mmol) in 30 mL of THF, was stirred at room temperature overnight. The mixture was added to 20 mL of water, extracted with EA, washed with water and brine, dried over Na2SO4. The volatiles were removed in vacuo to give 4.2 g of N,N-dimethyl-1-(4-nitrophenyl)piperidine-4-carboxamide. MS (m/z)=278 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434726B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-50e724b041f8481db32ad1c93d67fdcd |
| 출처 메모 | uspto-grants-2016_09 |