Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 57694생성일: 2026년 10월 23일
Diisopropylethylamine → Tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate
https://huagongshe.com/ko/reaction/57694
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1-BOC-3-Aminopiperidine | HCID 545809 | — |
| 반응물 | 6-Chloro-3-nitropyridin-2-ylamine | HCID 2724035 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Tert-butyl 3-[(6-amino-5-nitropyridin-2-yl)amino]piperidine-1-carboxylate | HCID 57911762 | — |
반응 단계
500 mg (2.11 mmol) of tert-butyl 3-aminopiperidine-1-carboxylate, 772 mg (4.22 mmol) of 2-amino-6-chloro-3-nitropyridine and 1.05 ml (6.34 mmol) of diisopropylethylamine were suspended in 18 ml of DMSO and heated in a microwave reactor at 120° C. for 45 min. The reaction mixture was purified by preparative reverse-phase HPLC. This gave 600 mg (81% of theory) of the product as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09434731B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-168e6acda84543759bf4d6b4fd981bc9 |
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| 출처 메모 | uspto-grants-2016_09 |
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