Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(R)-2-amino-3-methylbutanamide → 5-((1-methyl-1H-indol-4-yl)amino)-3-(((5-oxopyrrolidin-2-yl)methyl)amino)-1,2,4-triazine-6-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (R)-2-amino-3-methylbutanamide | HCID 444079 | — |
| 반응물 | 5-(Aminomethyl)pyrrolidin-2-one | HCID 14143189 | — |
| 반응물 | (R)-3-((1-amino-3-methyl-1-oxobutan-2-yl)amino)-5-((1-methyl-1H-indol-4-yl)amino)-1,2,4-triazine-6-carboxamide | HCID 86706423 | — |
| 생성물 | 5-((1-methyl-1H-indol-4-yl)amino)-3-(((5-oxopyrrolidin-2-yl)methyl)amino)-1,2,4-triazine-6-carboxamide | HCID 86706422 | — |
반응 단계
The title compound was prepared in a similar procedure as described in Example (R)-3-((1-amino-3-methyl-1-oxobutan-2-yl)amino)-5-((1-methyl-1H-indol-4-yl)amino)-1,2,4-triazine-6-carboxamide. Here though, 5-(aminomethyl)pyrrolidin-2-one was utilized instead of (R)-2-amino-3-methylbutanamide. MS found for C18H20N8O2 as (M+H)+ 381.3. UV: λ=219, 239, 292 nm. Proton NMR: (CD3OD) δ 7.90 (1H, d, J=8.0 Hz), 7.36-7.22 (3H, m), 6.60 (1H, dd, J=0.8 Hz, 2.8 Hz), 3.98 (1H, m), 3.84 (3H, s), 3.62-3.51 (2H, m), 2.40, −2.20 (3H, m), 1.90 (1H, m) ppm.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09040530B2 |
| 출처 데이터셋 | uspto-grants-2015_05 |
| ORD ID | ord-9f1d139deb72439c83c98d1fa749157b |
| 출처 메모 | uspto-grants-2015_05 |