Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 57972생성일: 2026년 10월 24일
N,N'-Dimethylethylenediamine → 1-(6-Bromo-2-pyridyl)-6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridine
https://huagongshe.com/ko/reaction/57972
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-6-iodo-3-methoxypyridine | HCID 11099040 | — |
| 반응물 | 6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine | HCID 86707080 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 생성물 | 1-(6-Bromo-2-pyridyl)-6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridine | HCID 86707154 | 64.6% |
반응 단계
A solution containing 6-(6-methylpyrazin-2-yl)-1H-pyrazolo[4,3-c]pyridine (250 mg, 1.18 mmol), 2-bromo-6-iodo-3-methoxypyridine (570 mg, 1.78 mmol), Copper(I) iodide (225 mg, 1.18 mmol), Potassium carbonate (196 mg, 1.42 mmol) and N,N′-Dimethylethylenediamine (0.25 mL, 2.37 mmol) was stirred at 85° C. 4 h. The reaction was filtered through celite and concentrated. The crude product purified by isco column (EtOAc/Hep eluted at 100% EtOAc) to give the desired product 280 mg 59% yield. MS (ESI) m/z: 397.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09434725B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-bcdd45b0245d474dbf6f5047b3cb492c |
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| 출처 메모 | uspto-grants-2016_09 |
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