참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2-Bromomethyl-1,4-benzodioxane | HCID 98333 | — |
| 반응물 | N-(4-piperidinylmethyl)-2-benzothiazolamine dihydrobromide | HCID 14048948 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | R 47243 | HCID 128556 | — |
반응 단계
A mixture of 3.8 parts of 2-(bromomethyl)-2,3-dihydro-1,4-benzodioxin, 6.3 parts of N-(4-piperidinylmethyl)-2-benzothiazolamine dihydrobromide, 10 parts of sodium carbonate, 0.1 parts of sodium iodide and 68 parts of N,N-dimethylformamide was stirred for 48 hours at 70° C. The reaction mixture was poured into water and the product was extracted with 4-methyl-2-pentanone. The extract was dried, filtered and evaporated. The oily residue was crystallized from acetonitrile, yielding 2.8 parts of N-[[1-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-4-piperidinyl]methyl]-2-benzothiazolamine; mp. 139.9° C. (compound 1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04749702 |
|---|
| 출처 데이터셋 | uspto-grants-1988_06 |
|---|
| ORD ID | ord-6c2392972407475a91be53061ada228e |
|---|
| 출처 메모 | uspto-grants-1988_06 |
|---|
