Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4H,6H-1,3,4-thiadiazin-5-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 4H-pyran-4-one | HCID 7968 | — |
| 반응물 | 2-(4-aminophenyl)-4H,6H-1,3,4-thiadiazin-5-one | HCID 15045645 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-[4-(4-Oxo-1,4-dihydropyridin-1-yl)phenyl]-4H,6H-1,3,4-thiadiazin-5-one | HCID 19794215 | — |
반응 단계
A stirred mixture of 2-(4-aminophenyl)-4H,6H-1,3,4-thiadiazin-5-one (1.0 g), 4H-pyran-4-one (0.51 g), water (20 ml) and concentrated hydrochloric acid (0.42 ml), was heated under reflux for 3 hours. The warm solution was neutralised with concentrated aqueous ammonia and cooled to give a solid, 1.33 g. Recrystallisation from methanol gave the title compound, 0.89 g, m.p. 289°-291° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05246928 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-4206414e65394297bb38130b22a09378 |
| 출처 메모 | uspto-grants-1993_09 |