Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiazole-5-carboxylic acid → N-(7-Chloro-1,8-naphthyridin-2-yl)-5-thiazolecarboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiazole-5-carboxylic acid | HCID 84494 | — |
| 반응물 | 7-Chloro-1,8-naphthyridin-2-amine | HCID 85199 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(7-Chloro-1,8-naphthyridin-2-yl)-5-thiazolecarboxamide | HCID 13983408 | 68% |
반응 단계
The procedure is similar to that described in Example 2, but starting with 5-thiazolecarboxylic acid (4.5 g), N,N'-carbonyldiimidazole (6.8 g) and 2-amino-7-chloro-1,8-naphthyridine (5 g). The product obtained by precipitation in water is purified by recrystallization in a dimethylformamide/acetonitrile (5:5 by volume) mixture (120 cc). N-(7-Chloro-1,8-naphthyridin-2-yl)-5-thiazolecarboxamide (5.5 g), m.p. 292° C., is thereby obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04753941 |
| 출처 데이터셋 | uspto-grants-1988_06 |
| ORD ID | ord-8f0a3522ed364424b0f2c82f36caa01d |
| 출처 메모 | uspto-grants-1988_06 |