Hydrochloric Acid → 10-(cis-3-Amino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid hydrochloride

참여 물질

반응 단계

A mixture of 10-(cis-3-t-butoxycarbonylamino-4-methyl-1-pyrrolidinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid (0.55 g) in ethanol (8 ml) and ethanolic hydrochloride solution (10 ml) was stirred for 2 hours at room temperature and then concentrated. To the resulting residue was added ethanol and the resulting precipitate was collected by filtration and then washed with hot ethanol to give the title compound (0.5 g) as yellowish powder, mp 298° C. (decompd.)

출처 및 근거