참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 2-Phenyl-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole | HCID 760886 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 10731614 | HCID 10731614 | 82% |
반응 단계
3.35 g of 5,6,7,8-tetrahydro-2-phenylimidazo[2,1-b]benzothiazole was suspended in 20 ml of dimethylformamide. To the resultant mixture, 3 ml of phosphorus oxychloride was added dropwise at 0° C. over 10 minutes. The solution was gradually returned to room temperature, then heated and stirred at 60° C. for 3 hours, poured onto an aqueous sodium carbonate solution, then extracted with chloroform. The solvent was distilled off, the residue was then recrystallized from ethanol to obtain the desired substance in an amount of 2.31 g (yield of 82.0%) (melting point:150-150.5° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05919799 |
|---|
| 출처 데이터셋 | uspto-grants-1999_07 |
|---|
| ORD ID | ord-d1941fde172f477b96484c5054a58e59 |
|---|
| 출처 메모 | uspto-grants-1999_07 |
|---|
