Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methylamine → 6-chloro-N-methylpyrimidin-4-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | 4,6-Dichloropyrimidine | HCID 70943 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 6-chloro-N-methylpyrimidin-4-amine | HCID 309479 | 62% |
반응 단계
To a solution of 4,6-dichloro-pyrimidine (7.45 g, 50 mmol) in iPrOH (50 mL) was added a solution of methyl amine in THF (2M, 30 mL, 60 mmol) at room temperature. The resulting mixture was stirred for 18 hours. The mixture was concentrated and the residue was purified by flash chromatography on silica eluting with DCM:EtOAc=6:1-1:1 to obtain the title compound (4.4 g, yield: 62%) as a white solid. 1H NMR (400 MHz, CDCl3) δ 2.96 (d, 3H), 5.22-5.36 (bs, 1H), 6.35 (s, 1H), 8.35 (s, 11H); MS (ESI): 144 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09434697B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-be2f740bdb93431cbfa5a50b841b792a |
| 출처 메모 | uspto-grants-2016_09 |