Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Veratrole → 3,4-Dimethoxybenzophenone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Veratrole | HCID 7043 | — |
| 반응물 | Benzoyl chloride | HCID 7412 | — |
| 반응물 | Bis(3,4-dimethoxyphenyl)methanone | HCID 223042 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 생성물 | 3,4-Dimethoxybenzophenone | HCID 286742 | — |
반응 단계
3,4-Dimethoxybenzophenone was prepared analogously to 3,4,3',4'-tetramethoxybenzophenone using veratrole (2 mL, 15 mmol), aluminum chloride (2.2 g, 16.5 mmol) and benzoyl chloride (1.8 mL, 15.5 mmol). The crude mixture was purified by flash column chromatography (silica gel, 3% ethyl acetate/methylene chloride) to yield 3.44 g (93%) of the product as a white solid: mp 99-100° C.; 1H NMR (CDCl3) δ 7.82-7.30(m, 7H), 6.95-6.85 (m, 1H), 3.96 (s, 3H), 3.94 (s, 3H); 13C NMR (CDCl3) δ 195.5, 153.0, 149.0, 138.2, 131.8, 130.2, 129.6, 128.1, 125.4, 112.1, 109.7, 56.0, 56.0; Anal. Calcd for C15H14O3. Theoretical: C, 74.36; H, 5.82. Found: C, 74.21; H, 6.01.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05929117 |
| 출처 데이터셋 | uspto-grants-1999_07 |
| ORD ID | ord-d42586159a8841cca8f416680f3f499c |
| 출처 메모 | uspto-grants-1999_07 |