2-Isoxazoline-3-carboxylic acid, 5-phenyl-, ethyl ester → 5-Phenyl-4,5-dihydro-1,2-oxazole-3-carboxylic acid

참여 물질

반응 단계

Ethyl 5-phenyl-4,5-dihydroisoxazole-3-carboxylate (0.1 g; 0.4 mmol) was dissolved in a mixture of sodium hydroxide (5 mL, 1M, water) and dioxane (2 mL). The reaction mixture was stirred vigorously at room temperature overnight and concentrated under reduced pressure. The resulting solution was acidified and extracted with ethyl acetate, dried and concentrated under reduced pressure, the crude material was used without further purification.

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