Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chloro-6-isothiocyanatotoluene → 1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chloro-6-isothiocyanatotoluene | HCID 90021 | — |
| 반응물 | 4-Methyloxazol-2-amine | HCID 535824 | — |
| 반응물 | Dichloromethane methanol | HCID 21226129 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-(4-Chloro-2-methyl-phenyl)-3-(4-methyl-oxazol-2-yl)-thiourea | HCID 9921816 | — |
반응 단계
Prepared using Method A from 4.04 g (22 mmol) of 4-chloro-2-methyl-phenyl isothiocyanate and 2.16 g (22 mmol) of 2-amino-4-methyloxazole to give 4.5 g of crude title compound. Pure title compound was obtained by flash chromatography (silica Merck 60, CH2Cl2—CH3OH, 19:1) and crystallization from CH3CN to give 2.12 g of the title compound as a yellow solid (72.5% yield, m.p. 214° C. with decomposition).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06936630B2 |
| 출처 데이터셋 | uspto-grants-2005_08 |
| ORD ID | ord-c70b46d569054d3fb0d1ed8f7d81116e |
| 출처 메모 | uspto-grants-2005_08 |