참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-Bromocyclohexene | HCID 137057 | — |
| 반응물 | Methyl 4-acetamido-5-chloro-2-hydroxybenzoate | HCID 13329485 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Methyl 2-(cyclohexen-3-yloxy)-4-acetylamino-5-chlorobenzoate | HCID 14621154 | — |
반응 단계
A mixture of 2.5 g methyl 4-acetylamino-5chlorosalicylate, 2 g of 3-bromocyclohexene, 2 g K2CO3 and 30 ml DMF are combined and heated at 110° C. overnight. The reaction mixture is then poured into water, filtered, dried and then extracted into ether. The ether solution is treated with charcoal, filtered and evaporated to dryness to obtain methyl 2-(cyclohexen -3-yloxy)-4-acetylamino-5-chlorobenzoate. This is then purified by recrystallization from ether/hexane. (M.P. 100°-102° C.)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05246942 |
|---|
| 출처 데이터셋 | uspto-grants-1993_09 |
|---|
| ORD ID | ord-a899c80f18084f9c9768df737127ddcc |
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| 출처 메모 | uspto-grants-1993_09 |
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