Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2-Fluoro-4-iodobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 2-Fluoro-4-iodobenzoic acid | HCID 2774516 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Fluoro-4-iodobenzamide | HCID 21904755 | — |
반응 단계
The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 2-fluoro-4-iodobenzoic acid (5.00 g, 18.0 mmol), oxalyl chloride (2.0 mL, 22.0 mmol), ammonia gas, DCM (100 mL) and THF (100 mL) to afford 2.00 g of the desired product. 1H NMR (300 MHz, DMSO d6): δ 7.40 (t, J=7.8 Hz, 1H), 7.63-7.76 (m, 1H); MS (m/z): 266.19 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09439890B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-608a80d74a534b1ca94e9867f20cd1e0 |
| 출처 메모 | uspto-grants-2016_09 |