Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-4-fluorobenzoic acid → 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-4-fluorobenzoic acid | HCID 75259 | — |
| 반응물 | 2,2,2-Trifluoro-N-(hydroxymethyl)acetamide | HCID 3084931 | — |
| 용매 | Sulfuric Acid | HCID 1118 | — |
| 생성물 | 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid | HCID 89736668 | 667,543% |
반응 단계
The title compound was prepared according to the procedure described in step-1 of Intermediate-26 by using 2-chloro-4-fluorobenzoic acid (5.0 g, 0.002 mmol), 2,2,2-trifluoro-N-(hydroxymethyl)acetamide (4.0 g, 0.002 mmol) and conc. H2SO4 (50 mL) to afford 4.0 g of the desired product. 1H NMR (400 MHz, DMSO d6): δ 4.44 (d, J=12.0 Hz, 2H), 7.59 (m, 1H), 7.92 (m, 1H), 10.0 (br s, 1H), 13.5 (br s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09439890B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-ad3c3e64c52a49f889c04540331e0030 |
| 출처 메모 | uspto-grants-2016_09 |