Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 5((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 5-((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid | HCID 89736668 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5((2,2,2-Trifluoroacetamido)methyl)-2-chloro-4-fluorobenzamide | HCID 90019517 | — |
반응 단계
The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 5-((2,2,2-trifluoroacetamido)methyl)-2-chloro-4-fluorobenzoic acid (1.0 g), oxalyl chloride (1.0 mL), THF (50 mL) and ammonia gas to afford 0.800 g of the desired product. 1H NMR (400 MHz, DMSO d6): δ 4.53 (m, 2H), 7.43 (m, 1H) 7.44 (m, 2H), 7.48 (m, 1H), 10.0 (br s, 1H)); MS (m/z): 297.10 (M−H)−.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09439890B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-4d6561c410114ef5a3525abf089e6be1 |
| 출처 메모 | uspto-grants-2016_09 |