참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | (Phenylmethyl)hydrazine | HCID 11157 | — |
| 반응물 | 2-Oxo-4-phenylbutyric acid | HCID 69732 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | 3,4-Dichloro-6-phenylpyridazine | HCID 13163231 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3,4-Dichloro-6-phenylpyridazine | HCID 13163231 | — |
| 생성물 | HCID 13342056 | HCID 13342056 | — |
| 생성물 | 3-Methoxy-4-chloro-6-phenylpyridazine | HCID 66731998 | — |
반응 단계
3,4-Dichloro-6-phenylpyridazine was synthesized from -oxobenzenebutanoic acid and 1-(phenylmethyl)hydrazine in 2 steps according to a procedure by Sircar (Sircar, I. J. Het. Chem. 1983, 20, 1473-1476.) 3,4-Dichloro-6-phenylpyridazine (100 mg, 0.44 mmol) was combined with sodium methoxide (1.1 mL of a 0.50M solution in methanol, 0.55 mmol, 1.25 equiv.) and methanol (296 μl, 1.5M) in a resealable tube and heated to 65° C. for 1 hour. The methanol was evaporated in vacuo, and water was added to the residue. The mixture was extracted with DCM, dried over K2CO3, filtered and concentrated in vacuo, to afford 3,4-dimethoxy-6-phenylpyridazine and 3-methoxy-4-chloro-6-phenylpyridazine, the title compound, as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09242961B2 |
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| 출처 데이터셋 | uspto-grants-2016_01 |
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| ORD ID | ord-aeb9557379b24d819e6a8de6c2dc59d9 |
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| 출처 메모 | uspto-grants-2016_01 |
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