참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 6-Methoxypyridazin-3-amine | HCID 81673 | — |
| 반응물 | 4-((3,5-Dimethylisoxazol-4-yl)methoxy)benzene-1-sulfonyl chloride | HCID 16490702 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | HCID 117925948 | HCID 117925948 | 4.1% |
반응 단계
To a solution of 6-methoxypyridazin-3-amine (125 mg, 1.0 mmol) in pyridine (8 mL) at room temperature, was added 4-{[(3,5-dimethyl-4-isoxazolyl)methyl]oxy}benzenesulfonyl chloride (0.302 g, 1.0 mmol). The reaction mixture was stirred at 20° C. for 18 hours. The solvent was evaporated in vacuo and passed through an aminopropyl (NH2) solid phase extraction (SPE) cartridge eluting with methanol, followed by a sulphonic acid (SCX) SPE cartridge eluting with methanol. The crude was then purified by flash silica (Si) chromatography (0-100% ethyl acetate-cyclohexane+0-25% methanol gradient), to provide the title compound (16 mg). LCMS (2 min, formic) Rt 0.83 min, m/z (ES+) 391 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09242972B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_01 |
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| ORD ID | ord-a6f100bcc13f4355b07a0d68d4972464 |
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| 출처 메모 | uspto-grants-2016_01 |
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