Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzoic Acid → N'-benzoyl-6-chloro-4-(isopropylamino)nicotinohydrazide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzoic Acid | HCID 243 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | 6-Chloro-4-(isopropylamino)nicotinohydrazide | HCID 89689668 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N'-benzoyl-6-chloro-4-(isopropylamino)nicotinohydrazide | HCID 89689702 | — |
반응 단계
6-chloro-4-(isopropylamino)nicotinohydrazide (10) (500 mg, 2.1 mmol) and benzoic acid (2.1 mmol, 1 equiv.) were dissolved in DMF (10 mL). EDC.HCl (1.5 equiv.), DIPEA (3 equiv.) and HOBT (1.5 equiv.) were added to the reaction mixture and stirred at room temperature for 5 h. The reaction mass was concentrated under reduced pressure to remove excess of solvent present. Diluted the residue with EtOAc and washed water followed by brine solution. The organic layer was collected, dried over Na2SO4, filtered and concentrated to get N′-benzoyl-6-chloro-4-(isopropylamino)nicotinohydrazide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09242975B2 |
| 출처 데이터셋 | uspto-grants-2016_01 |
| ORD ID | ord-4cc06ae56bfc4f3fb1b9aef0139a49f5 |
| 출처 메모 | uspto-grants-2016_01 |