참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2-Amino-3-bromopyridine | HCID 817700 | — |
| 반응물 | 3-Fluoro-4-(methoxycarbonyl)benzeneboronic acid | HCID 2782818 | — |
| 촉매 | HCID 178418807 | HCID 178418807 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Methyl 4-(2-aminopyridin-3-yl)-2-fluorobenzoate | HCID 118046154 | 79% |
반응 단계
To 3-bromopyridin-2-amine (5 g, 28.9 mmol) in 500 mL round bottom flask was added (3-fluoro-4-(methoxycarbonyl)phenyl)boronic acid (7.44 g, 37.6 mmol), PdCl2(dppf)-DCM (2.115 g, 2.89 mmol), DME (108 mL) and 2M Na2CO3 solution (36.1 mL). The reaction mixture was heated in an oil bath at 110° C. for 4 h. The reaction mixture was diluted with EtOAc and washed with water three times, dried over Na2SO4, filtered and concentrated. The crude product was purified by flash chromatography eluting with 0-100% of EtOAc (containing 10% of MeOH)/heptane yielding 5.6 g of methyl 4-(2-aminopyridin-3-yl)-2-fluorobenzoate in 79% yield. LCMS (m/z): 247.1 (MH+), 0.50 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09242996B2 |
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| 출처 데이터셋 | uspto-grants-2016_01 |
|---|
| ORD ID | ord-8974d23a49d24df49ab13feee8f313c8 |
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| 출처 메모 | uspto-grants-2016_01 |
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