Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → N-Acetyl-L-phenylalanine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 2-(Acetylamino)-3-phenyl-2-propenoic acid | HCID 95631 | — |
| 반응물 | Diphosphane | HCID 139283 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | N-Acetyl-L-phenylalanine | HCID 74839 | 82% |
반응 단계
3.1 mg of the complex of the formula [RhCl-1,5-cyclooctadiene]2, 57 mg of the diphosphine of Example 1 and 400 cm3 of ethyl alcohol are introduced under an argon atmosphere into a reactor. The mixture is stirred for 1 hour. 66.62 g of α-acetamidocinnamic acid and 25 microlitres of triethylamine are then added and hydrogen is introduced under a pressure of 1 bar at 25° C. After 4 hours 30 minutes the hydrogenation is complete. After treatment to remove the catalyst similar to that of Example 5, N-acetylphenylalanine is obtained, after extraction, in 97% chemical yield and with an optical rotation [α]D22 of 42.5° (optical yield 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04010181 |
| 출처 데이터셋 | uspto-grants-1977_03 |
| ORD ID | ord-7b78a90c575e417c880f20ee6c4b724e |
| 출처 메모 | uspto-grants-1977_03 |