Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formic Acid → tert-Butyl (4-Cyano-2-(methylsulfonyl)phenyl)(phenylsulfonyl)methylcarbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formic Acid | HCID 284 | — |
| 반응물 | tert-Butyl carbamate | HCID 77922 | — |
| 반응물 | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| 반응물 | 4-Formyl-3-(methylsulfonyl)benzonitrile | HCID 58133750 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | tert-Butyl (4-Cyano-2-(methylsulfonyl)phenyl)(phenylsulfonyl)methylcarbamate | HCID 86732345 | — |
반응 단계
Formic acid (6.2 mL, 164 mmol) is added to a mixture of tert-butyl carbamate (3.05 g, 26.0 mmol), 4-formyl-3-(methylsulfonyl)benzonitrile (5.44 g, 26.0 mmol, preparation according to WO09080199) and sodium benzenesulfinate (4.27 g, 26.0 mmol) in THF (10.0 mL) and water (25.0 mL) and the reaction mixture is stirred at room temperature for 4 days. Water (30 mL) is added and the precipitate is filtered off, washed with water and acetonitrile and dried. Yield: 5.10 g. ESI mass spectrum: [M+H]+=451; Retention time HPLC: 0.59 min (X012_S01).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09440930B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-582eeaa3a7854d5db29ff3a2da6a047e |
| 출처 메모 | uspto-grants-2016_09 |