참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methylamine | HCID 6329 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 5-Bromo-1,3-difluoro-2-nitrobenzene | HCID 21335487 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 5-Bromo-3-fluoro-N-methyl-2-nitroaniline | HCID 71652038 | — |
반응 단계
2 M MeNH2 in THF (82 mL) was added dropwise to a solution of 5-bromo-1,3-difluoro-2-nitrobenzene (164 mmol) and Cs2CO3 (197 mmol) in THF (1 L). The reaction mixture was stirred at 0° C. for 1 h and then at room temperature for 1 h. The solvent was removed under reduced pressure. The residue was partitioned between EtOAc and H2O. The two phases were separated and the organic layer was dried (Na2SO4) and concentrated to afford the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09440929B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-dbfc8f0c4dbe4079969af08fe4403998 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
