Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(2-Cyanoethylaminocarbonyl)benzeneboronic acid → (S)-N-((S)-1-Cyano-2-(3'-(2-cyanoethylcarbamoyl)biphenyl-4-yl)ethyl)piperidine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(2-Cyanoethylaminocarbonyl)benzeneboronic acid | HCID 3690598 | — |
| 반응물 | (S)-tert-Butyl 2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate | HCID 57999629 | — |
| 생성물 | (S)-N-((S)-1-Cyano-2-(3'-(2-cyanoethylcarbamoyl)biphenyl-4-yl)ethyl)piperidine-2-carboxamide | HCID 42641214 | — |
반응 단계
Prepared by a process analogous to that described in Method 2 Example 2 using (S)-tert-butyl 2-((S)-1-cyano-2-(4-iodophenyl)ethylcarbamoyl)piperidine-1-carboxylate and 3-(2-cyanoethylcarbamoyl)phenylboronic acid. NMR appeared to show the product was a free base.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07902181B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-d9a1cef1b27f4107977bac98126baed7 |
| 출처 메모 | uspto-grants-2011_03 |