Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4,4-Difluorocyclohexyl)amine → 5-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyrazine-2-carboxylic acid (4,4-difluoro-cyclohexyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4,4-Difluorocyclohexyl)amine | HCID 3847030 | — |
| 반응물 | 5-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyrazine-2-carboxylic acid | HCID 68444054 | — |
| 생성물 | 5-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyrazine-2-carboxylic acid (4,4-difluoro-cyclohexyl)-amide | HCID 42636271 | 27% |
반응 단계
As described for example 2b, 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyrazine-2-carboxylic acid (100 mg, 0.32 mmol) was converted, using 4,4-difluorocyclohexylamine instead of aminomethylcyclopropane to the title compound (SiO2, heptane:ethyl acetate=90:10 to 60:40, 37 mg, 27%) which was obtained as a white solid. MS: m/e=429.2 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07902201B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-a7917bd9cd0e4e61a9cbd0dcc5b22f92 |
| 출처 메모 | uspto-grants-2011_03 |