참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chlorotrimethylsilane | HCID 6397 | — |
| 반응물 | Hexamethyldisilazane | HCID 13838 | — |
| 반응물 | Lysine hydrochloride, D- | HCID 81691 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | D-2-Aminohexano-6-lactam | HCID 439823 | — |
반응 단계
To a solution of (R)-lysine HCl salt (100 g, 0.68 mol) in xylene (1 L) was added hexamethyldisilazane (1000 mL, 4.76 mol) and chlorotrimethylsilane (10 mL, 78.8 mmol). The mixture was heated to 120° C. for 24 h, then to 180° C. for 48 h. The solvent was then removed under reduced pressure and the crude material was purified by column chromatography (20:1 to 10:1 CH2Cl2/MeOH) to afford (R)-3-aminoazepan-2-one (I-1a).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09440957B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-6d4b5949406f44f498638a066d6521b7 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
