Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
18-Crown-6 → 2-Benzenesulfonylmethyl-benzooxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 18-Crown-6 | HCID 28557 | — |
| 반응물 | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| 반응물 | 2-(Bromomethyl)benzo[d]oxazole | HCID 12745944 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Benzenesulfonylmethyl-benzooxazole | HCID 12475398 | 70% |
반응 단계
To 9.1 g (0.043 mol) of 2-bromomethyl-benzooxazole in CH3CN (300 mL) were added 7.39 g (0.045 mol, 1.05 eq) of benzenesulfinic acid sodium salt and 2.27 g (8.6 mmol, 0.2 eq) of 18-crown-6. Stirring was continued overnight, solvent evaporated and a column chromatography afforded 8.1 g (70%) of 2-benzenesulfonylmethyl-benzooxazole as a white solid, MS: 274 (H+). (Y. Nagao, S. Yamada, E. Fujita, Tet. Lett., 1983, 24, 2291)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07906546B2 |
| 출처 데이터셋 | uspto-grants-2011_03 |
| ORD ID | ord-c29c9a0c22224811a7955def82770b32 |
| 출처 메모 | uspto-grants-2011_03 |